ARG54262
anti-CD266 / TWEAK R antibody [ITEM-4] (PE)
anti-CD266 / TWEAK R antibody [ITEM-4] (PE) for Flow cytometry and Human,Mouse
Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [ITEM-4] recognizes CD266 / TWEAK R |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | FACS |
| 特异性 | The clone ITEM-4 recognizes CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | ITEM-4 |
| 同位型 | IgG2b |
| 靶点名称 | CD266 / TWEAK R |
| 抗原物种 | Human |
| 抗原 | human CD266-transfected P815 cells |
| 偶联标记 | PE |
| 別名 | Tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; CD266; Fibroblast growth factor-inducible immediate-early response protein 14; TWEAKR; TweakR; CD antigen CD266; Tweak-receptor; FN14 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9CR75 Mouse Tumor necrosis factor receptor superfamily member 12A Swiss-port # Q9NP84 Human Tumor necrosis factor receptor superfamily member 12A |
|---|---|
| 基因名称 | TNFRSF12A |
| 全名 | tumor necrosis factor receptor superfamily, member 12A |
| 背景介绍 | CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential. |
| 生物功能 | Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody |
| 预测分子量 | 14 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG54262 anti-CD266 / TWEAK R antibody [ITEM-4] (PE) FACS image
Flow Cytometry: Separation of unstained (black-dashed) and stained (red-filled) CD266 transfected L51784 cells. Cells were stained with ARG54262 anti-CD266 / TWEAK R antibody [ITEM-4] (PE) at 0.19 µg/ml dilution.
克隆号文献
TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor.
