ARG42385
anti-CD255 / TWEAK antibody [CARL-1] (PE)
anti-CD255 / TWEAK antibody [CARL-1] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [CARL-1] recognizes CD255 / TWEAK |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | CARL-1 |
| 同位型 | IgG3, kappa |
| 靶点名称 | CD255 / TWEAK |
| 抗原物种 | Human |
| 抗原 | Human CD255-transfected 2PK-3 cells. |
| 偶联标记 | PE |
| 別名 | APO3L; DR3LG; TWEAK; TNLG4A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O43508 Human Tumor necrosis factor ligand superfamily member 12 |
|---|---|
| 基因名称 | TNFSF12 |
| 全名 | TNF superfamily member 12 |
| 背景介绍 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010] |
| 生物功能 | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. [UniProt] |
| 细胞定位 | Plasma membrane; Extracellular region or secreted. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42385 anti-CD255 / TWEAK antibody [CARL-1] (PE) FACS image
Flow Cytometry: Separation of CD255 transfected L5178Y cells (red-filled) from non-transfected L5178Y cells (black-dashed). Cells were stained with ARG42385 anti-CD255 / TWEAK antibody [CARL-1] (PE) (10 µl reagent / 10^6 cells in 100 µl of cell suspension).
