ARG65541
anti-CD24 antibody [SN3] (FITC)
anti-CD24 antibody [SN3] (FITC) for Flow cytometry and Human
Cancer antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [SN3] recognizes CD24 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The antibody SN3 reacts with CD24, a 3545 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes. HLDA IV; WS Code B 136 HLDA V; WS Code B CD24.7 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SN3 |
| 同位型 | IgG1 |
| 靶点名称 | CD24 |
| 抗原物种 | Human |
| 抗原 | Glycoproteins purified from human NALM-1 cell line. |
| 偶联标记 | FITC |
| 別名 | Signal transducer CD24; CD antigen CD24; CD24A; Small cell lung carcinoma cluster 4 antigen |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD24 |
| 全名 | CD24 molecule |
| 背景介绍 | CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4; it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid. |
| 生物功能 | Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. [UniProt] |
| 研究领域 | Cancer antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody |
| 预测分子量 | 8 kDa |
| 翻译后修饰 | Extensively O-glycosylated. |
检测图片 (2) Click the Picture to Zoom In
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ARG65541 anti-CD24 antibody [SN3] (FITC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG65541 anti-CD24 antibody [SN3] (FITC) (20 µl reagent / 100 µl of peripheral whole blood).
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ARG65541 anti-CD24 antibody [SN3] (FITC) FACS image
Flow Cytometry: Separation of human CD24 positive lymphocytes (red-filled) from monocytes (black-dashed). Human peripheral whole blood stained with ARG65541 anti-CD24 antibody [SN3] (FITC) (20 µl reagent / 100 µl of peripheral whole blood).
克隆号文献
Taxane-induced hedgehog signaling is linked to expansion of breast cancer stem-like populations after chemotherapy.
Enrichment of breast cancer stem-like cells by growth on electrospun polycaprolactone-chitosan nanofiber scaffolds.
FACS /
CD24 expression predicts distant metastasis in extrahepatic bile duct cancer.
IHC / Human
CD44/CD24 immunophenotypes on clinicopathologic features of salivary glands malignant neoplasms.
IHC / Human
CD24: a potential new marker in differentiating malignant mesothelioma from pulmonary adenocarcinoma.
IHC / Human
Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics.
FACS / Human
FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1.
ICC/IF / Human
The role of extracellular factors in human metastatic chordoma cell growth in vitro.
WB / Human
