ARG45080
anti-CD230 / Prion protein Phospho (Ser43) antibody
anti-CD230 / Prion protein Phospho (Ser43) antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD230 / Prion protein Phospho (Ser43) |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD230 / Prion protein |
| 抗原物种 | Human |
| 抗原 | Prion Protein (Ser-43) antibody was generated from a phospho-peptide that included amino acids surrounding Serine 43 in human prion protein. This sequence has high homology to the conserved site in rat, mouse, and bovine prion protein. |
| 偶联标记 | Un-conjugated |
| 別名 | PRNP; Prion Protein (Kanno Blood Group); AltPrP; PRP ; CD230; PRIP; Alternative Prion Protein; Major Prion Protein; Prion Protein; CD230 Antigen; PrP33-35C; PrP27-30; P27-30; ASCR; CJD; GSS; Gerstmann-Strausler-Scheinker Syndrome; Creutzfeldt-Jakob Disease; Fatal Familial Insomnia; Prion Protein (P27-30); Prion-Related Protein; ALTPRP; KURU; PrPc; PrP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antigen Affinity Purified. |
| 缓冲液 | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| 稳定剂 | 50% Glycerol and 0.1 % BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PRNP |
| 全名 | Prion Protein (Kanno Blood Group) |
| 背景介绍 | The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| 生物功能 | Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or Zn2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains. [Uniprot] |
| 细胞定位 | Amyloid, Cell membrane, Golgi apparatus, Membrane. [Uniprot] |
| 预测分子量 | 28 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein. [Uniprot] |
