ARG40397
anti-CD222 / IGF2R antibody
anti-CD222 / IGF2R antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD222 / IGF2R |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD222 / IGF2R |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human CD222 / IGF2R. |
| 偶联标记 | Un-conjugated |
| 別名 | MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P11717 Human Cation-independent mannose-6-phosphate receptor Swiss-port # Q07113 Mouse Cation-independent mannose-6-phosphate receptor |
|---|---|
| 基因名称 | IGF2R |
| 全名 | insulin like growth factor 2 receptor |
| 背景介绍 | This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015] |
| 生物功能 | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. [UniProt] |
| 细胞定位 | Lysosome membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 274 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG40397 anti-CD222 / IGF2R antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human colon stained with ARG40397 anti-CD222 / IGF2R antibody.
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ARG40397 anti-CD222 / IGF2R antibody WB image
Western blot: Jurkat cell lysate stained with ARG40397 anti-CD222 / IGF2R antibody.
