ARG59665
anti-CD194 / CCR4 antibody
anti-CD194 / CCR4 antibody for Western blot and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD194 / CCR4 |
|---|---|
| 反应物种 | Ms, Rat |
| 预测物种 | Bov |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD194 / CCR4 |
| 抗原物种 | Mouse |
| 抗原 | Synthetic peptide corresponding to aa. 346-360 of Mouse CCR4. (SYTQSTVDHDFRDAL) |
| 偶联标记 | Un-conjugated |
| 別名 | CD194; ChemR13; K5-5; C-C chemokine receptor type 4; CCR-4; HGCN:14099; CKR4; CD antigen CD194; CC-CKR-4; CCR4; C-C CKR-4; CMKBR4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Thimerosal and 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CCR4 |
| 全名 | chemokine (C-C motif) receptor 4 |
| 背景介绍 | The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008] |
| 生物功能 | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 41 kDa |
| 翻译后修饰 | In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG59665 anti-CD194 / CCR4 antibody WB image
Western blot: 50 µg of Rat thymus, 50 µg of Rat spleen and 40 µg of HEPA whole cell lysates stained with ARG59665 anti-CD194 / CCR4 antibody at 0.5 µg/ml dilution.
