ARG42450
anti-CD172b / SIRPB1 antibody [B4B6] (PE)
anti-CD172b / SIRPB1 antibody [B4B6] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [B4B6] recognizes CD172b / SIRPB1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody B4B6 recognizes an extracellular epitope of CD172b, an approximately 50 kDa transmembrane glycoprotein expressed on myeloid cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | B4B6 |
| 同位型 | IgG1 |
| 靶点名称 | CD172b / SIRPB1 |
| 抗原物种 | Human |
| 抗原 | NIH/3T3 cells transfected with Human CD172b. |
| 偶联标记 | PE |
| 別名 | CD antigen CD172b; CD172b; CD172 antigen-like family member B; SIRP-BETA-1; SIRP-beta-1; Signal-regulatory protein beta-1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SIRPB1 |
| 全名 | signal-regulatory protein beta 1 |
| 背景介绍 | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| 生物功能 | Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985). [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 43 kDa |
| 翻译后修饰 | N-glycosylated. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42450 anti-CD172b / SIRPB1 antibody [B4B6] (PE) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG42450 anti-CD172b / SIRPB1 antibody [B4B6] (PE).
