ARG42427
anti-CD170 / Siglec 5 antibody [1A5]
anti-CD170 / Siglec 5 antibody [1A5] for ELISA,Flow cytometry,ICC/IF,IHC-Frozen sections,Immunoprecipitation and Human,Primates
概述
| 产品描述 | Mouse Monoclonal antibody [1A5] recognizes CD170 / Siglec 5 |
|---|---|
| 反应物种 | Hu, NHuPrm |
| 应用 | ELISA, FACS, ICC/IF, IHC-Fr, IP |
| 特异性 | The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5, sialic acid binding Ig-like lectin 5), a transmembrane glycoprotein expressed strongly by neutrophils, macrophages activated during infections, monocytes, and dendritic cells. As in case with other anti-CD170 antibodies, this antibody crossreacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1A5 |
| 同位型 | IgG1 |
| 靶点名称 | CD170 / Siglec 5 |
| 抗原物种 | Human |
| 抗原 | Fusion protein composed of Human CD170 extracellular domain and Fc region of Human IgG1. |
| 偶联标记 | Un-conjugated |
| 別名 | OBBP2; OB-binding protein 2; CD170; Sialic acid-binding Ig-like lectin 5; SIGLEC-5; CD antigen CD170; CD33 antigen-like 2; OB-BP2; CD33L2; Siglec-5; Obesity-binding protein 2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O15389 Human Sialic acid-binding Ig-like lectin 5 |
|---|---|
| 基因名称 | SIGLEC5 |
| 全名 | sialic acid binding Ig-like lectin 5 |
| 背景介绍 | This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |
| 生物功能 | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 61 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42427 anti-CD170 / Siglec 5 antibody [1A5] FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG42427 anti-CD170 / Siglec 5 antibody [1A5], followed by APC-conjugated Goat anti-Mouse antibody.
