ARG54259
anti-CD161 antibody [HP-3G10] (PE)
anti-CD161 antibody [HP-3G10] (PE) for Flow cytometry and Human,Primates
Developmental Biology antibody; Immune System antibody
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [HP-3G10] recognizes CD161 |
|---|---|
| 反应物种 | Hu, NHuPrm |
| 应用 | FACS |
| 特异性 | The clone HP-3G10 recognizes CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | HP-3G10 |
| 同位型 | IgG1 |
| 靶点名称 | CD161 |
| 抗原物种 | Human |
| 抗原 | human NK cells |
| 偶联标记 | PE |
| 別名 | CLEC5B; CD antigen CD161; CD161; NKR-P1; NKR-P1A; Killer cell lectin-like receptor subfamily B member 1; NKRP1A; NKR; HNKR-P1a; Natural killer cell surface protein P1A; C-type lectin domain family 5 member B; hNKR-P1A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q12918 Human Killer cell lectin-like receptor subfamily B member 1 |
|---|---|
| 基因名称 | KLRB1 |
| 全名 | killer cell lectin-like receptor subfamily B, member 1 |
| 背景介绍 | CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on a majority of NK cells, NKT cells, and e.g. Th17 cells and CD3+ thymocytes. Although rat CD161 has three isoforms (a, b, c), the human CD161 is expressed as one isoform. |
| 生物功能 | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. [UniProt] |
| 研究领域 | Developmental Biology antibody; Immune System antibody |
| 预测分子量 | 25 kDa |
| 翻译后修饰 | N-glycosylated. Contains sialic acid residues. |
检测图片 (1) Click the Picture to Zoom In
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ARG54259 anti-CD161 antibody [HP-3G10] (PE) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG54259 anti-CD161 antibody [HP-3G10] (PE).
克隆号文献
CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase.
