ARG54305
anti-CD158f / KIR2DL5 antibody [UP-R1] (PE)
anti-CD158f / KIR2DL5 antibody [UP-R1] (PE) for Flow cytometry and Human
Immune System antibody
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [UP-R1] recognizes CD158f |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody UPR1 recognizes CD158f (KIR2DL5), a 60 kDa glycoprotein serving as a HLA class I ligand, and mainly expressed on a subset of NK cells and a small population of T cells. Its expression is highly polymorphic between individuals. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | UP-R1 |
| 同位型 | IgG1 |
| 靶点名称 | CD158f / KIR2DL5 |
| 抗原物种 | Human |
| 抗原 | Human CD158f-Ig fusion protein |
| 偶联标记 | PE |
| 別名 | CD antigen CD158f1; KIR2DL5.3; KIR2DL5.1; Killer cell immunoglobulin-like receptor 2DL5A; KIR2DL5; CD158F |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8N109 Human Killer cell immunoglobulin-like receptor 2DL5A |
|---|---|
| 基因名称 | KIR2DL5A |
| 全名 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A |
| 背景介绍 | CD158f, also known as KIR2DL5, is a polymorphic 60 kDa transmembrane glycoprotein with two Ig-like extracellular domains by which it recognize HLA class I molecules. Its long intracellular domain contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that upon extracellular ligand-mediated phosphorylation serve as docking sites for inhibitory phosphatases, which results in blocking natural cytotoxicity as well as antibody-dependent cytotoxicity of the particular NK cell, and its adhesion toward target cells. Together with other killer inhibitory receptors CD158f is important for immunological tolerance to discriminate between normal and abnormal cells. Besides NK cells it is expressed on a small population of cytotoxic T cells. Expression of CD158f alleles is highly variable in the population. |
| 生物功能 | Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 41 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG54305 anti-CD158f / KIR2DL5 antibody [UP-R1] (PE) FACS image
Flow Cytometry: Human peripheral blood stained with ARG54305 anti-CD158f / KIR2DL5 antibody [UP-R1] (PE).
