ARG62732
anti-CD147 antibody [MEM-M6/2]
anti-CD147 antibody [MEM-M6/2] for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections and Human,Pig
Cancer antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody
概述
| 产品描述 | Mouse Monoclonal antibody [MEM-M6/2] recognizes CD147 |
|---|---|
| 反应物种 | Hu, Pig |
| 应用 | FACS, IHC-P |
| 特异性 | The clone MEM-M6/2 recognizes extracellular Ig domain D1 of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes. MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MEM-M6/2 |
| 同位型 | IgG2b |
| 靶点名称 | CD147 |
| 抗原物种 | Human |
| 抗原 | A soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the entire extracellular region of CD147 fused to the DNA coding for the hinge region, CH2 and CH3 domain of human IgG1. |
| 偶联标记 | Un-conjugated |
| 別名 | OK; Tumor cell-derived collagenase stimulatory factor; Leukocyte activation antigen M6; TCSF; Extracellular matrix metalloproteinase inducer; OK blood group antigen; CD147; Basigin; M6; EMMPRIN; Collagenase stimulatory factor; CD antigen CD147; 5F7 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | IHC-P: Testis |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from ascites by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BSG |
| 全名 | basigin (Ok blood group) |
| 背景介绍 | CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated forms. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function. |
| 生物功能 | Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. [UniProt] |
| 研究领域 | Cancer antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody |
| 预测分子量 | 42 kDa |
| 翻译后修饰 | N-glycosylated. |
克隆号文献
Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions.
WB / Human
