ARG21322

anti-CD11c antibody [3.9]

anti-CD11c antibody [3.9] for Flow cytometry,IHC-Frozen sections,Immunoprecipitation,Blocking and Human,Rhesus Monkey

Overview

Product Description Mouse Monoclonal antibody [3.9] recognizes CD11c
Tested Reactivity Hu, R. Mk
Tested Application BL, FACS, IHC-Fr, IP
Specificity Human/Rhesus/Cynomolgus CD11c.
Host Mouse
Clonality Monoclonal
Clone 3.9
Isotype IgG1κ
Target Name CD11c
Antigen Species Human
Immunogen Rheumatoid synovial cells and human monocytes
Conjugation Un-conjugated
Full Name integrin, alpha X (complement component 3 receptor 4 subunit)
Alternate Names CD antigen CD11c; Leu M5; CD11C; SLEB6; Integrin alpha-X; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11 antigen-like family member C

Application Instructions

Application Suggestion
Application Dilution
BLAssay-dependent
FACS< 1 µg/10^6 cells
IHC-FrAssay-dependent
IPAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer BBS (pH 8.2)
Concentration 0.1 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 3687 Human ITGAX

Swiss-port # P20702 Human Integrin alpha-X

Gene Symbol ITGAX
Gene Full Name integrin, alpha X (complement component 3 receptor 4 subunit)
Background This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Function Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [UniProt]