ARG22709
anti-CD11a + CD18 antibody [CVS9]
anti-CD11a + CD18 antibody [CVS9] for Flow cytometry,IHC-Frozen sections and Horse
概述
| 产品描述 | Mouse Monoclonal antibody [CVS9] recognizes CD11a + CD18 This antibody recognizes Equine homolog of the Human CD11a/CD18 cell surface antigen, a hetrodimer expressed on all equine cells of haemopoietic origin. Studies have indicated that equine CD11a/CD18 has higher expression on some subpopulations of T-cells. |
|---|---|
| 反应物种 | Hrs |
| 应用 | FACS, IHC-Fr |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | CVS9 |
| 同位型 | IgG1 |
| 靶点名称 | CD11a + CD18 |
| 抗原物种 | Horse |
| 抗原 | Equine leucocytes. |
| 偶联标记 | Un-conjugated |
| 別名 | Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA1A; LFA-1A; Integrin alpha-L; CD11A; Leukocyte function-associated molecule 1 alpha chain; LFA-1; CD11 antigen-like family member A; CD antigen CD11a |
应用说明
| 应用建议 |
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| 应用说明 | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | ITGAL |
|---|---|
| 全名 | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
| 背景介绍 | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. [UniProt] |
| 预测分子量 | 129 kDa |
| 翻译后修饰 | In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents. |
检测图片 (1) Click the Picture to Zoom In
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ARG22709 anti-CD11a + CD18 antibody [CVS9] FACS image
Flow Cytometry: Equine peripheral blood lymphocytes stained with ARG22709 anti-CD11a + CD18 antibody [CVS9], followed by Goat anti-Mouse IgG (FITC).
