ARG54253
anti-CD107b / LAMP2 antibody [H4B4] (PE)
anti-CD107b / LAMP2 antibody [H4B4] (PE) for Electron microscopy,Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Purification,Western blot and Human,African green monkey,Rhesus Monkey
Cell Biology and Cellular Response antibody; Cell Death antibody; Controls and Markers antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [H4B4] recognizes CD107b / LAMP2 |
|---|---|
| 反应物种 | Hu, AGMK, R. Mk |
| 应用 | EM, FACS, ICC/IF, IHC-Fr, IHC-P, Puri, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | H4B4 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD107b / LAMP2 |
| 抗原物种 | Human |
| 抗原 | Human adherent peripheral blood cells |
| 偶联标记 | PE |
| 別名 | CD antigen CD107b; LAMPB; CD107b; LGP110; Lysosome-associated membrane glycoprotein 2; LAMP-2; CD107 antigen-like family member B; Lysosome-associated membrane protein 2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS, 0.1% Sodium azide and Sucrose. |
| 抗菌剂 | 0.1% Sodium azide |
| 稳定剂 | Sucrose |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P13473 Human Lysosome-associated membrane glycoprotein 2 |
|---|---|
| 基因名称 | LAMP2 |
| 全名 | lysosomal-associated membrane protein 2 |
| 背景介绍 | CD107b (lysosome-associated membrane protein-2, LAMP-2), together with CD107a / LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa. |
| 生物功能 | Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody; Controls and Markers antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody |
| 预测分子量 | 45 kDa |
| 翻译后修饰 | O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans. |
检测图片 (1) Click the Picture to Zoom In
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ARG54253 anti-CD107b / LAMP2 antibody [H4B4] (PE) FACS image
Flow Cytometry: Jurkat cells stained with ARG54253 anti-CD107b / LAMP2 antibody [H4B4] (PE).
克隆号文献
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
WB, ICC/IF / Human
Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.
Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate.
IHC-FoFr / Macaque Monkey
Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration.
FACS / Human
Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome.
ICC/IF / African Green Monkey
