ARG67260
anti-CD105 / Endoglin antibody [SQab30376]
anti-CD105 / Endoglin antibody [SQab30376] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Monoclonal antibody [SQab30376] recognizes CD105 / Endoglin. |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30376 |
| 同位型 | IgG |
| 靶点名称 | CD105 / Endoglin |
| 抗原 | Synthetic peptide. |
| 偶联标记 | Un-conjugated |
| 別名 | ENG; Endoglin; END; HHT1; CD105 Antigen; CD105; ORW1; Osler-Rendu-Weber Syndrome 1; Soluble Endoglin; ORW |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ENG |
| 全名 | Endoglin |
| 背景介绍 | This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] |
| 生物功能 | Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3. [Uniprot] |
| 细胞定位 | Cell membrane, Membrane. [Uniprot] |
| 预测分子量 | 71 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Phosphoprotein. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
-
ARG67260 anti-CD105 / Endoglin antibody [SQab30376] IHC-P image
Immunohistochemistry: Human Liver Cancer stained with ARG67260 anti-CD105 / Endoglin antibody [SQab30376] at 1:100 dilution.
