ARG23526
anti-CD105 / Endoglin antibody [SN6] (PE)
anti-CD105 / Endoglin antibody [SN6] (PE) for Flow cytometry and Human,Horse,Rhesus Monkey
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [SN6] recognizes CD105 / Endoglin. Mouse anti Human CD105 antibody, clone SN6 recognizes the human endoglin, also known as CD105. CD105 is a glycoprotein homodimer of 95 kDa subunits expressed by endothelial cells, activated monocytes and some leukemia cells. |
|---|---|
| 反应物种 | Hu, Hrs, R. Mk |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SN6 |
| 同位型 | IgG1 |
| 靶点名称 | CD105 / Endoglin |
| 抗原物种 | Human |
| 抗原 | Partially purified cell membrane antigens from fresh leukemia cells. |
| 偶联标记 | PE |
| 別名 | CD antigen CD105; HHT1; Endoglin; ORW1; END |
应用说明
| 应用建议 |
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| 应用说明 | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS, 0.09% Sodium azide, 1% BSA and 5% Sucrose. |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 1% BSA and 5% Sucrose |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ENG |
| 全名 | endoglin |
| 背景介绍 | This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] |
| 生物功能 | Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3. [UniProt] |
| 预测分子量 | 71 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG23526 anti-CD105 / Endoglin antibody [SN6] (PE) FACS image
Flow Cytometry: KG1 cells stained with ARG23526 anti-CD105 / Endoglin antibody [SN6] (PE).
