ARG22348
anti-CD105 / Endoglin antibody [SN6]
anti-CD105 / Endoglin antibody [SN6] for Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Purification,Western blot and Human,Horse
概述
| 产品描述 | Mouse Monoclonal antibody [SN6] recognizes CD105 / Endoglin |
|---|---|
| 反应物种 | Hu, Hrs |
| 应用 | FACS, ICC/IF, IHC-Fr, IHC-P, IP, Puri, WB |
| 特异性 | Human CD105 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SN6 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD105 / Endoglin |
| 抗原物种 | Human |
| 抗原 | Antigen preparation isolated from cell membranes of leukemia cells derived from a patient with non-T/non-B-cell acute lymphoblastic leukemia. |
| 偶联标记 | Un-conjugated |
| 別名 | CD antigen CD105; HHT1; Endoglin; ORW1; END |
应用说明
| 应用建议 |
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| 应用说明 | WB: Under non-reducing condition. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | BBS (pH 8.2) |
| 浓度 | 0.1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ENG |
| 全名 | endoglin |
| 背景介绍 | This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] |
| 生物功能 | Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3. [UniProt] |
| 预测分子量 | 71 kDa |
