ARG65507
anti-CD105 / Endoglin antibody [MJ7/18]
anti-CD105 / Endoglin antibody [MJ7/18] for Flow cytometry,IHC-Frozen sections,Immunoprecipitation,Western blot and Mouse
Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Immune System antibody
概述
| 产品描述 | Rat Monoclonal antibody [MJ7/18] recognizes CD105 / Endoglin |
|---|---|
| 反应物种 | Ms |
| 应用 | FACS, IHC-Fr, IP, WB |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | MJ7/18 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | CD105 / Endoglin |
| 抗原物种 | Mouse |
| 抗原 | Inflamed mouse skin |
| 偶联标记 | Un-conjugated |
| 別名 | CD antigen CD105; HHT1; Endoglin; ORW1; END |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | BBS (pH 8.2) |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Eng |
| 全名 | endoglin |
| 背景介绍 | CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
| 生物功能 | Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Immune System antibody |
| 预测分子量 | 71 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG65507 anti-CD105 / Endoglin antibody [MJ7/18] FACS image
Flow Cytometry: BALB/c Mouse endothelioma cell line bEnd.3 was stained with ARG65507 anti-CD105 / Endoglin antibody [MJ7/18] followed by ARG21704 Mouse anti-Rat IgG2a antibody [2A8F4] (PE).
克隆号文献
Osteogenic Potential of Mouse Adipose-Derived Stem Cells Sorted for CD90 and CD105 In Vitro.
FACS / Mouse
A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis.
WB /
Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature.
IHC-Fr /
Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice.
IHC-Fr /
Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis.
WB, IHC-Fr /
