ARG21041
anti-CD104 / Integrin beta 4 antibody [346-11A]
anti-CD104 / Integrin beta 4 antibody [346-11A] for Flow cytometry,ICC/IF,IHC-Frozen sections,Immunoprecipitation,Western blot and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [346-11A] recognizes CD104 / Integrin beta 4 |
|---|---|
| 反应物种 | Ms |
| 应用 | FACS, ICC/IF, IHC-Fr, IP, WB |
| 特异性 | Mouse CD104. The clone 346-11A can block this adhesion. |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 346-11A |
| 同位型 | IgG2a, kappa |
| 靶点名称 | CD104 / Integrin beta 4 |
| 抗原物种 | Mouse |
| 抗原 | Tumor-associated antigen TSP-180 purified from a transplantable BALB/c carcinoma |
| 偶联标记 | Un-conjugated |
| 別名 | Integrin beta-4; GP150; CD antigen CD104; CD104 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | BBS (pH 8.2) |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ITGB4 |
| 全名 | integrin beta 4 |
| 背景介绍 | Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. [UniProt] |
| 预测分子量 | 202 kDa |
| 翻译后修饰 | Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secundary association with tertaspanins. |
检测图片 (2) Click the Picture to Zoom In
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ARG21041 anti-CD104 / Integrin beta 4 antibody [346-11A] IHC-Fr image
Immunohistochemistry: C57BL/6 Mouse intestine stained with ARG21041 anti-CD104 / Integrin beta 4 antibody [346-11A].
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ARG21041 anti-CD104 / Integrin beta 4 antibody [346-11A] IHC-Fr image
Immunohistochemistry: Frozen section of BALB/c Mouse intestine tissue stained with ARG20701 Rat IgG2a Isotype Control antibody [KLH/G2a-1-1] (left) and ARG21041 anti-CD104 / Integrin beta 4 antibody [346-11A] (right) followed by ARG23770 Goat anti-Rat IgG (H+L) antibody (Biotin) (pre-adsorbed), Streptavidin (FITC), and DAPI.
