概述

产品描述	Rabbit Polyclonal antibody recognizes CC2D1A
反应物种	Hu, Ms, Rat
应用	IHC-P, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	CC2D1A
抗原物种	Human
抗原	Recombinant Protein of Human CC2D1A.
偶联标记	Un-conjugated
別名	MRT3; Five prime repressor element under dual repression-binding protein 1; Freud-1/Aki1; FREUD-1; Akt kinase-interacting protein 1; Putative NF-kappa-B-activating protein 023N; Freud-1; FRE under dual repression-binding protein 1; Coiled-coil and C2 domain-containing protein 1A

应用说明

应用建议	应用 推荐稀释比 IHC-P 1:50 - 1:200 WB 1:500-1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	SKOV3

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 212139 Mouse CC2D1A GeneID: 288908 Rat CC2D1A GeneID: 54862 Human CC2D1A Swiss-port # Q66HA5 Rat Coiled-coil and C2 domain-containing protein 1A Swiss-port # Q6P1N0 Human Coiled-coil and C2 domain-containing protein 1A Swiss-port # Q8K1A6 Mouse Coiled-coil and C2 domain-containing protein 1A More
基因名称	CC2D1A
全名	coiled-coil and C2 domain containing 1A
背景介绍	This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.[provided by RefSeq, Oct 2009]
生物功能	Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. [UniProt]
预测分子量	104 kDa
翻译后修饰	Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21.

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