ARG43210
anti-CBX1 / HP1 beta antibody
anti-CBX1 / HP1 beta antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CBX1 / HP1 beta |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CBX1 / HP1 beta |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-185 of Human CBX1 / HP1 beta (NP_006798.1). |
| 偶联标记 | Un-conjugated |
| 別名 | MOD1; Chromobox protein homolog 1; HP1 beta; M31; HP1Hs-beta; Modifier 1 protein; Heterochromatin protein p25; HP1-BETA; Heterochromatin protein 1 homolog beta; CBX; HP1Hsbeta; p25beta |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | OVCAR-3 | ||||
| 实际分子量 | ~ 25 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CBX1 |
| 全名 | chromobox homolog 1 |
| 背景介绍 | This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| 生物功能 | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. [UniProt] |
| 细胞定位 | Nucleus. Note=Unassociated with chromosomes during mitosis. [UniProt] |
| 预测分子量 | 21 kDa |
| 翻译后修饰 | Not phosphorylated. Ubiquitinated. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG43210 anti-CBX1 / HP1 beta antibody WB image
Western blot: 25 µg of OVCAR-3 cell lysate stained with ARG43210 anti-CBX1 / HP1 beta antibody at 1:1000 dilution.
