ARG56538
anti-CB1 Receptor antibody
anti-CB1 Receptor antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CB1 Receptor |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CB1 Receptor |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the C-terminus of Human Cannabinoid Receptor I . |
| 偶联标记 | Un-conjugated |
| 別名 | CB1K5; CNR; CB1R; Cannabinoid receptor 1; CB-R; CB1; CB1A; CANN6 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | TBS (pH 7.4), 0.02% Sodium azide, 50% Glycerol and 0.1% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CNR1 |
| 全名 | cannabinoid receptor 1 (brain) |
| 背景介绍 | This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009] |
| 生物功能 | Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. [UniProt] |
| 预测分子量 | 53 kDa |
| 翻译后修饰 | Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts. |
检测图片 (1) Click the Picture to Zoom In
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ARG56538 anti-CB1 Receptor antibody IHC-P image
Immunohistochemistry: Paraffin-embedded CA region of Rat hippocampus stained with ARG56538 anti-CB1 Receptor antibody. Majority of the protein is localized in the pre-synaptic axons, shown as brown particles. A few neurons also show cytoplasm staining.
