ARG45827
anti-CARD15 / NOD2 antibody
anti-CARD15 / NOD2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cell Biology and Cellular Response antibody; Cell Death antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CARD15 / NOD2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CARD15 / NOD2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to Human CARD15 / NOD2. |
| 偶联标记 | Un-conjugated |
| 別名 | NOD2; Nucleotide Binding Oligomerization Domain Containing 2; PSORAS1; CLR16.3; CARD15; NLRC2; BLAU; CD; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 2; Nucleotide-Binding Oligomerization Domain-Containing Protein 2; Caspase Recruitment Domain-Containing Protein 15; Caspase Recruitment Domain Family, Member 15; NLR Family, CARD Domain Containing 2; Inflammatory Bowel Disease Protein 1; NOD-Like Receptor C2; IBD1; Nucleotide-Binding Oligomerization Domain 2; Caspase Recruitment Domain Protein 15; BLAUS; NOD2B; ACUG; YAOS |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 30% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9HC29 Human Nucleotide-binding oligomerization domain-containing protein 2 |
|---|---|
| 基因名称 | NOD2 |
| 全名 | Nucleotide Binding Oligomerization Domain Containing 2 |
| 背景介绍 | This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
| 生物功能 | May also be involved in NLRP1 activation following activation by MDP, leading to CASP1 activation and IL1B release in macrophage. [Uniprot] |
| 细胞定位 | Cell membrane, Cytoplasm, Membrane, Mitochondrion. [Uniprot] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody |
| 预测分子量 | 115 kDa |
| 翻译后修饰 | Glycoprotein, Lipoprotein, Palmitate, Ubl conjugation. [Uniprot] |
检测图片 (3) Click the Picture to Zoom In
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ARG45827 anti-CARD15 / NOD2 antibody IHC-P image
Immunohistochemistry: Human colon stained with ARG45827 anti-CARD15 / NOD2 antibody.
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ARG45827 anti-CARD15 / NOD2 antibody WB image
Western blot: Rat spleen stained with ARG45827 anti-CARD15 / NOD2 antibody.
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ARG45827 anti-CARD15 / NOD2 antibody WB image
Western blot: Mouse kidney stained with ARG45827 anti-CARD15 / NOD2 antibody at dilution.
