ARG55410
anti-CARD11 antibody
anti-CARD11 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CARD11 |
|---|---|
| 反应物种 | Ms |
| 预测物种 | Hu |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CARD11 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within the last 50 aa of Human CARD11. |
| 偶联标记 | Un-conjugated |
| 別名 | BIMP3; BENTA; PPBL; Caspase recruitment domain-containing protein 11; Carma 1; CARD-containing MAGUK protein 1; IMD11; CARMA1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse Thymus Tissue Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8CIS0 Mouse Caspase recruitment domain-containing protein 11 |
|---|---|
| 基因名称 | CARD11 |
| 全名 | caspase recruitment domain family, member 11 |
| 背景介绍 | The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 133 kDa |
| 翻译后修饰 | Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling. |
检测图片 (3) Click the Picture to Zoom In
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ARG55410 anti-CARD11 antibody WB image
Western blot: 2 µg of Mouse thymus cell lysate stained with ARG55410 anti-CARD11 antibody.
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ARG55410 anti-CARD11 antibody IHC image
Immunohistochemistry: Mouse thymus stained with ARG55410 anti-CARD11 antibody at 10 µg/ml dilution.
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ARG55410 anti-CARD11 antibody ICC/IF image
Immunofluorescence: Mouse Spleen cells stained with ARG55410 anti-CARD11 antibody at 20 µg/ml dilution.
