ARG58361
anti-CAMLG antibody
anti-CAMLG antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CAMLG |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CAMLG |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-190 of Human CAMLG (NP_001736.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Calcium signal-modulating cyclophilin ligand; CAML |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HepG2 | ||||||||
| 实际分子量 | 38 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P49069 Human Calcium signal-modulating cyclophilin ligand |
|---|---|
| 基因名称 | CAMLG |
| 全名 | calcium modulating ligand |
| 背景介绍 | The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008] |
| 生物功能 | Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. [UniProt] |
| 细胞定位 | Membrane, Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 33 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG58361 anti-CAMLG antibody WB image
Western blot: 25 µg of HepG2 cell lysate stained with ARG58361 anti-CAMLG antibody at 1:3000 dilution.
