ARG22228
anti-CACNB2 antibody [S8B-1]
anti-CACNB2 antibody [S8B-1] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [S8B-1] recognizes CACNB2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 特异性 | Detects ~78 kDa. No cross reactivity against Cavβ1, Cavβ3, Cavβ4. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | S8B-1 |
| 同位型 | IgG1 |
| 靶点名称 | CACNB2 |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide around aa. 189-205 of Rat CACNB2 |
| 偶联标记 | Un-conjugated |
| 別名 | Lambert-Eaton myasthenic syndrome antigen B; CACNLB2; Voltage-dependent L-type calcium channel subunit beta-2; Calcium channel voltage-dependent subunit beta 2; CAVB2; CAB2; MYSB |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Cacnb2 |
| 全名 | calcium channel, voltage-dependent, beta 2 subunit |
| 背景介绍 | This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013] |
| 生物功能 | The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. [UniProt] |
| 细胞定位 | Cell membrane, Sarcolemma |
| 预测分子量 | 74 kDa |
| 翻译后修饰 | Regulated through phosphorylation at Thr-554 by CaMK2D. |
检测图片 (1) Click the Picture to Zoom In
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ARG22228 anti-CACNB2 antibody [S8B-1] WB image
Western blot: Human cell line lysates stained with ARG22228 anti-CACNB2 antibody [S8B-1] at 1:1000 dilution.
