ARG64446
anti-C14orf169 / NO66 antibody
anti-C14orf169 / NO66 antibody for Western blot and Human
Gene Regulation antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes C14orf169 / NO66 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | C14orf169 / NO66 |
| 抗原物种 | Human |
| 抗原 | C-GAQHSDSKDPR |
| 偶联标记 | Un-conjugated |
| 別名 | hsNO66; 60S ribosomal protein L8 histidine hydroxylase; EC 1.14.11.27; MAPJD; Myc-associated protein with JmjC domain; ROX; URLC2; Ribosomal oxygenase NO66; EC 1.14.11.-; NO66; Nucleolar protein 66; Histone lysine demethylase NO66; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9H6W3 Human Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 |
|---|---|
| 基因名称 | C14orf169 |
| 全名 | chromosome 14 open reading frame 169 |
| 生物功能 | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt] |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 71 kDa |
检测图片 (1) Click the Picture to Zoom In
-
ARG64446 anti-C14orf169 / NO66 antibody WB image
Western Blot: A431 cell lysate (35 µg protein in RIPA buffer) stained with ARG64446 anti-C14orf169 / NO66 antibody at 0.3 µg/ml dilution.
