ARG40728
anti-Bcl 3 antibody
anti-Bcl 3 antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Bcl 3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Bcl 3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 300-400 of Human Bcl 3 (NP_005169.2). |
| 偶联标记 | Un-conjugated |
| 別名 | BCL4; BCL-3; B-cell lymphoma 3 protein; Proto-oncogene BCL3; D19S37 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 48 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BCL3 |
| 全名 | B-cell CLL/lymphoma 3 |
| 背景介绍 | This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008] |
| 生物功能 | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Ubiquitination via 'Lys- 63'-linked ubiquitin chains is required for nuclear accumulation. [UniProt] |
| 预测分子量 | 48 kDa |
| 翻译后修饰 | Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity). Activated by phosphorylation. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG40728 anti-Bcl 3 antibody WB image
Western blot: 25 µg of A549 cell lysate stained with ARG40728 anti-Bcl 3 antibody at 1:1000 dilution.
