ARG55820
anti-Bcl 10 antibody [1185CT13.2.1.2]
anti-Bcl 10 antibody [1185CT13.2.1.2] for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes Bcl 10 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1185CT13.2.1.2 |
| 同位型 | IgG1, kappa |
| 靶点名称 | Bcl 10 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 1-143 of Human Bcl 10. |
| 偶联标记 | Un-conjugated |
| 別名 | B-cell CLL/lymphoma 10; Cellular homolog of vCARMEN; cCARMEN; IMD37; CIPER; c-E10; Mammalian CARD-containing adapter molecule E10; Bcl-10; CED-3/ICH-1 prodomain homologous E10-like regulator; mE10; CARD-containing molecule enhancing NF-kappa-B; B-cell lymphoma/leukemia 10; hCLAP; Cellular-E10; CARMEN; CLAP; CARD-like apoptotic protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Daudi |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BCL10 |
| 全名 | B-cell CLL/lymphoma 10 |
| 背景介绍 | This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. [UniProt] |
| 细胞定位 | Cytoplasm, perinuclear region. Membrane raft. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts |
| 预测分子量 | 26 kDa |
| 翻译后修饰 | Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB. |
检测图片 (3) Click the Picture to Zoom In
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ARG55820 anti-Bcl 10 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue stained with ARG55820 anti-Bcl 10 antibody at 1:25 dilution.
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ARG55820 anti-Bcl 10 antibody WB image
Western blot: 35 µg of Daudi cell lysate stained with ARG55820 anti-Bcl 10 antibody at 1:1000 dilution.
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ARG55820 anti-Bcl 10 antibody FACS image
Flow Cytometry: HeLa cells stained with ARG55820 anti-Bcl 10 antibody (right histogram) at 1:25 dilution or isotype control antibody (left histogram), followed by incubation with Alexa Fluor® 488 labelled secondary antibody.
