ARG54152
anti-BRAP antibody
anti-BRAP antibody for Western blot and Human
Gene Regulation antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody recognizes BRAP |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | BRAP |
| 抗原物种 | Human |
| 抗原 | Purified recombinant human BRAP protein fragments expressed in E.coli. |
| 偶联标记 | Un-conjugated |
| 別名 | BRAP; BRCA1 Associated Protein; BRAP2; RNF52; IMP; Impedes Mitogenic Signal Propagation; RING-Type E3 Ubiquitin Transferase BRAP2; Renal Carcinoma Antigen NY-REN-63; Galectin-2-Binding Protein; BRCA1-Associated Protein; RING Finger Protein 52; EC 2.3.2.27 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 67 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1.8 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BRAP |
| 全名 | BRCA1 associated protein |
| 背景介绍 | The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008] |
| 生物功能 | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 研究领域 | Gene Regulation antibody; Signaling Transduction antibody |
| 预测分子量 | 67 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG54152 anti-BRAP antibody WB image
Western blot: A549 cell lysate stained with ARG54152 anti-BRAP antibody at 1:500 dilution.
