概述

产品描述	Rabbit Polyclonal antibody recognizes BPGM
反应物种	Hu, Ms, Rat
应用	ICC/IF, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	BPGM
抗原物种	Human
抗原	Recombinant Protein of Human BPGM.
偶联标记	Un-conjugated
別名	2,3-diphosphoglycerate mutase; BPGM; Bisphosphoglycerate mutase; DPGM; EC 5.4.2.11; 2,3-bisphosphoglycerate synthase; EC 5.4.2.4; BPG-dependent PGAM; EC 3.1.3.13; 2,3-bisphosphoglycerate mutase, erythrocyte

应用说明

应用建议	应用 推荐稀释比 ICC/IF 1:50 - 1:200 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Mouse spleen

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 12183 Mouse BPGM GeneID: 669 Human BPGM Swiss-port # P07738 Human Bisphosphoglycerate mutase Swiss-port # P15327 Mouse Bisphosphoglycerate mutase
基因名称	BPGM
全名	2,3-bisphosphoglycerate mutase
背景介绍	2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
生物功能	Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities. [UniProt]
预测分子量	30 kDa
翻译后修饰	Glycation of Lys-159 in diabetic patients inactivates the enzyme.

检测图片 (1) Click the Picture to Zoom In