ARG45739
anti-BMPR1A antibody
anti-BMPR1A antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes BMPR1A |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | BMPR1A |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to middle region of human BMPR1A. |
| 偶联标记 | Un-conjugated |
| 別名 | BMPR1A; bone morphogenetic protein receptor, type IA; CD292; CD antigen CD292; ALK3; ACVRLK3; ALK-3; EC 2.7.11.30; Activin receptor-like kinase 3; 10q23del; Serine/threonine-protein kinase receptor R5; BMPR-1A; BMP type-1A receptor; SKR5; Bone morphogenetic protein receptor type-1A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 60 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P36894 Human Bone morphogenetic protein receptor type-1A Swiss-port # Q78EA7 Rat Bone morphogenetic protein receptor type-1A |
|---|---|
| 基因名称 | BMPR1A |
| 全名 | bone morphogenetic protein receptor, type IA |
| 背景介绍 | The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008] |
| 生物功能 | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 60 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG45739 anti-BMPR1A antibody IHC-P image
Immunohistochemistry: Human breast cancer stained with ARG45739 anti-BMPR1A antibody at 2 μg/ml dilution.
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ARG45739 anti-BMPR1A antibody WB image
Western blot: 293T stained with ARG45739 anti-BMPR1A antibody at 0.5 μg/ml dilution.
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ARG45739 anti-BMPR1A antibody FACS image
Flow Cytometry: MCF-7 stained with ARG45739 anti-BMPR1A antibody at 1 µg/10^6 cells dilution.
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ARG45739 anti-BMPR1A antibody WB image
Western blot: Rat skeletal muscle stained with ARG45739 anti-BMPR1A antibody at 0.5 μg/ml dilution.
