ARG59631
anti-BLMH antibody
anti-BLMH antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes BLMH |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Rb |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | BLMH |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 212-242 of Human BLMH. |
| 偶联标记 | Un-conjugated |
| 別名 | BLM hydrolase; BMH; BH; EC 3.4.22.40; Bleomycin hydrolase |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | K562 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BLMH |
| 全名 | bleomycin hydrolase |
| 背景介绍 | Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008] |
| 生物功能 | The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 53 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG59631 anti-BLMH antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human skin tissue stained with ARG59631 anti-BLMH antibody at 1:25 dilution.
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ARG59631 anti-BLMH antibody WB image
Western blot: 35 µg of K562 cell lysate stained with ARG59631 anti-BLMH antibody.
