ARG43823
anti-BIM antibody
anti-BIM antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes BIM |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 特异性 | Human,Mouse,Rat |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | BIM |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of human Bim. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Bcl-2-like protein 11 |
| 別名 | BCL2L11; BCL2 Like 11; BIM; BOD; BCL2-Like 11 (Apoptosis Facilitator); Bcl-2-Like Protein; BimEL; BimL; BimS; Bcl-2 Interacting Mediator Of Cell Death; Bcl2-Interacting Mediator Of Cell Death; Bcl-2-Related Ovarian Death Agonist; Bcl-2 Interacting Protein Bim; Bcl2-L-11; BAM |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 实际分子量 | 22 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | Tris-Glycine, 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BCL2L11 |
| 全名 | BCL2 Like 11 |
| 背景介绍 | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013] |
| 生物功能 | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. [UniProt] |
| 细胞定位 | Membrane, Mitochondrion. [UniProt] |
| 预测分子量 | 22 kDa |
| 翻译后修饰 | Phosphoprotein, Ubl conjugation. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG43823 anti-BIM antibody WB image
Western blot: Rat spleen and PC-12 stained with ARG43823 anti-BIM antibody at 1:500 dilution.
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ARG43823 anti-BIM antibody WB image
Western blot: 3T3 and HeLa stained with ARG43823 anti-BIM antibody at 1:500 dilution.
