ARG56653
anti-BDNF antibody
anti-BDNF antibody for ELISA,ICC/IF,IHC-Frozen sections,Neutralizing,Western blot and Human,Mouse,Rat
参考文献3
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes BDNF |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, ICC/IF, IHC-Fr, Neut, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | BDNF |
| 抗原物种 | Human |
| 抗原 | E.coli derived Recombinant Human BDNF. (MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR) |
| 偶联标记 | Un-conjugated |
| 別名 | Brain-derived neurotrophic factor; Abrineurin; BULN2; ANON2; BDNF |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.2) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BDNF |
| 全名 | brain-derived neurotrophic factor |
| 背景介绍 | The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009] |
| 生物功能 | During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. [UniProt] |
| 产品亮点 | Related products: BDNF antibodies; BDNF ELISA Kits; BDNF recombinant proteins; Anti-Rabbit IgG secondary antibodies; Related news: The role of HDGF in tumor angiogenesis |
| 预测分子量 | 28 kDa |
| 翻译后修饰 | The propeptide is N-glycosylated and glycosulfated. Converted into mature BDNF by plasmin (PLG). |
检测图片 (2) Click the Picture to Zoom In
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ARG56653 anti-BDNF antibody ICC/IF image (Citation paper)
XU, Jing, et al. Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats. Biology, 2023, 12.1: 99.
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ARG56653 anti-BDNF antibody WB image
Western blot: 250 - 0.24 ng of Human BDNF stained with ARG56653 anti-BDNF antibody, under reducing conditions.
文献引用
Targeting blood brain barrier-Remote ischemic conditioning alleviates cognitive impairment in female APP/PS1 rats
WB / Rat
Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats
WB / Rat
Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats
WB/IHC-Fr / Rat
