ARG65694
anti-BCOR / BCL6 corepressor antibody
anti-BCOR / BCL6 corepressor antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Gene Regulation antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes BCOR / BCL6 corepressor |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | BCOR / BCL6 corepressor |
| 抗原物种 | Human |
| 抗原 | Synthesized peptide around aa. 1200-1280 (Center) of Human BCoR. |
| 偶联标记 | Un-conjugated |
| 別名 | BCL-6 corepressor; ANOP2; MCOPS2; BCoR; MAA2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol, 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BCOR |
| 全名 | BCL6 corepressor |
| 背景介绍 | The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010] |
| 生物功能 | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). [UniProt] |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 192 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG65694 anti-BCOR / BCL6 corepressor antibody WB image
Western blot: COLO205 cells stained with ARG65694 anti-BCOR / BCL6 corepressor antibody.
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ARG65694 anti-BCOR / BCL6 corepressor antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast carcinoma tissue stained with ARG65694 anti-BCOR / BCL6 corepressor antibody (left), or the same antibody pre-incubated with antigen (right).
