ARG40157

anti-BAIAP2L1 antibody

anti-BAIAP2L1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

概述

产品描述 Rabbit Polyclonal antibody recognizes BAIAP2L1
反应物种 Hu
预测物种 Ms, Rat
应用 IHC-P, WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 BAIAP2L1
抗原物种 Human
抗原 Fusion protein of Human BAIAP2L1.
偶联标记 Un-conjugated
別名 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; IRTKS; BAI1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate

应用说明

应用建议
应用 推荐稀释比
IHC-P1:25 - 1:100
WB1:500 - 1:2000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 WB: HepG2, HeLa, A172, A549 and A431.
IHC-P: Human esophagus cancer and human thyroid cancer.

属性

形式 Liquid
纯化 Affinity purification with immunogen.
缓冲液 PBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol.
抗菌剂 0.05% Sodium azide
稳定剂 40% Glycerol
浓度 1 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 55971 Human BAIAP2L1

Swiss-port # Q9UHR4 Human Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein

基因名称 BAIAP2L1
全名 BAI1-associated protein 2-like 1
背景介绍 This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]
生物功能 May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. [UniProt]
细胞定位 Cytoplasm, cytoskeleton. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites. [UniProt]
预测分子量 57 kDa
翻译后修饰 Phosphorylated on tyrosine in response to insulin. [UniProt]

检测图片 (3) Click the Picture to Zoom In

  • ARG40157 anti-BAIAP2L1 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human esophagus cancer stained with ARG40157 anti-BAIAP2L1 antibody (left) at 1:30 dilution, or the same antibody pre-incubated with antigen (right). (Original magnification: X200).

  • ARG40157 anti-BAIAP2L1 antibody WB image

    Western blot: 40 µg of HepG2, HeLa, A172, A549 and A431 cell lysates stained with ARG40157 anti-BAIAP2L1 antibody at 1:800 dilution.

  • ARG40157 anti-BAIAP2L1 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human thyroid cancer stained with ARG40157 anti-BAIAP2L1 antibody (left) at 1:30 dilution, or the same antibody pre-incubated with antigen (right). (Original magnification: X200).