ARG55432
anti-BAG2 antibody
anti-BAG2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes BAG2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Bov |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | BAG2 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 148-176 (C-terminus) of Human BAG2. |
| 偶联标记 | Un-conjugated |
| 別名 | BAG family molecular chaperone regulator 2; dJ417I1.2; Bcl-2-associated athanogene 2; BAG-2 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | NCI-H460 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O95816 Human BAG family molecular chaperone regulator 2 |
|---|---|
| 基因名称 | BAG2 |
| 全名 | BCL2-associated athanogene 2 |
| 背景介绍 | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] |
| 生物功能 | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody |
| 预测分子量 | 24 kDa |
检测图片 (2) Click the Picture to Zoom In
-
ARG55432 anti-BAG2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human ovarian carcinoma stained with ARG55432 anti-BAG2 antibody.
-
ARG55432 anti-BAG2 antibody WB image
Western blot: 35 µg of NCI-H460 cell lysate stained with ARG55432 anti-BAG2 antibody.
