ARG23528
anti-Apolipoprotein H antibody [ID2]
anti-Apolipoprotein H antibody [ID2] for IHC-Frozen sections,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [ID2] recognizes Apolipoprotein H. Mouse anti Human apolipoprotein H antibody, clone 1D2 recognizes the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1, APC inhibitor, activated protein C-binding protein or anticardiolipin cofactor. Apolipoprotein H is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, a process involved in the pathogenesis of recurrent miscarriage and thrombotic tendencies due to antiphospholipid syndrome. |
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| 反应物种 | Hu |
| 应用 | IHC-Fr, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | ID2 |
| 同位型 | IgG1 |
| 靶点名称 | Apolipoprotein H |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | Apo-H; Beta-2-glycoprotein 1; BG; B2G1; APC inhibitor; Apolipoprotein H; Anticardiolipin cofactor; B2GPI; Beta; 2; Activated protein C-binding protein; B2GP1; Beta-2-glycoprotein I |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
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| 纯化 | Tissue Culture Supernatant |
| 缓冲液 | Tissue Culture Supernatant and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
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| 基因名称 | APOH |
| 全名 | apolipoprotein H (beta-2-glycoprotein I) |
| 背景介绍 | Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008] |
| 生物功能 | Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. [UniProt] |
| 预测分子量 | 38 kDa |
| 翻译后修饰 | N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG23528 anti-Apolipoprotein H antibody [ID2] IHC-Fr image
Immunohistochemistry: Frozen section of an 8.6 week placenta stained with ARG23528 anti-Apolipoprotein H antibody [ID2].
