ARG66535
anti-Apelin antibody
anti-Apelin antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Apelin |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Apelin |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from the C-terminal region of Human Apelin. |
| 偶联标记 | Un-conjugated |
| 別名 | APJ endogenous ligand; Apelin; APEL; XNPEP2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | ~ 16 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | APLN |
| 全名 | apelin |
| 背景介绍 | This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010] |
| 生物功能 | Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. [UniProt] |
| 细胞定位 | Secreted. Secreted, extracellular space. Note=Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk. [UniProt] |
| 预测分子量 | 9 kDa |
| 翻译后修饰 | Several active peptides may be produced by proteolytic processing of the peptide precursor. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG66535 anti-Apelin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG66535 anti-Apelin antibody at 1:100 dilution.
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ARG66535 anti-Apelin antibody WB image
Western blot: 22RV-1, H460, U87 and Mouse brain lysates stained with ARG66535 anti-Apelin antibody.
