ARG43914
anti-Angiogenin antibody
anti-Angiogenin antibody for ELISA,Western blot and Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Angiogenin |
|---|---|
| 反应物种 | Rat |
| 应用 | ELISA, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Angiogenin |
| 抗原物种 | Rat |
| 抗原 | Rat Angiogenin recombinant protein |
| 表达系统 | E.coli |
| 偶联标记 | Un-conjugated |
| Protein Full name | Angiogenin |
| 別名 | ANG; Angiogenin; RNASE5; RAA1; Angiogenin, Ribonuclease, RNase A Family, 5; Ribonuclease A Family Member 5; Ribonuclease 5; RNase 5; Epididymis Luminal Protein 168; Ribonuclease A A1; EC 3.1.27.- ; EC 3.1.27; HEL168; RNASE4; ALS9 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | ANG |
|---|---|
| 全名 | Angiogenin |
| 背景介绍 | The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. |
| 生物功能 | Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). |
| 细胞定位 | Cytoplasmic vesicle, Nucleus, Secreted |
| 预测分子量 | 17 kDa |
| 翻译后修饰 | Disulfide bond, Pyrrolidone carboxylic acid |
检测图片 (1) Click the Picture to Zoom In
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ARG43914 anti-Angiogenin antibody WB image
Western blot: Rat liver stained withARG43914 anti-Angiogenin antibody at 0.5 μg/mL dilution.
