ARG11121
anti-Adenylate cyclase 3 antibody [1A12]
anti-Adenylate cyclase 3 antibody [1A12] for IHC-Frozen sections and Rat
概述
| 产品描述 | Mouse Monoclonal antibody [1A12] recognizes Adenylate cyclase 3 |
|---|---|
| 反应物种 | Rat |
| 预测物种 | Hu, Ms |
| 应用 | IHC-Fr |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1A12 |
| 同位型 | IgG1 |
| 靶点名称 | Adenylate cyclase 3 |
| 抗原物种 | Rat |
| 抗原 | KLH-conjugated synthetic peptide around the C-terminal region of Rat Adenylate cyclase 3. (C-PAAFPNGSSVTLPHQVVDNP) |
| 偶联标记 | Un-conjugated |
| 別名 | AC-III; Adenylate cyclase type III; AC3; ATP pyrophosphate-lyase 3; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; EC 4.6.1.1; Adenylate cyclase type 3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS, 5 mM Sodium azide and 50% Glycerol. |
| 抗菌剂 | 5 mM Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ADCY3 |
| 全名 | adenylate cyclase 3 |
| 背景介绍 | This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] |
| 生物功能 | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus. Note=Also detected in the cytoplasm, close to lipid droplets. [UniProt] |
| 预测分子量 | 129 kDa |
| 翻译后修饰 | Sumoylated. Sumoylation is required for targeting ot olfactory cilia. N-glycosylated. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG11121 anti-Adenylate cyclase 3 antibody [1A12] IHC-Fr image
Immunohistochemistry: Frozen section of caudate/putamen region of rat brain stained with ARG11121 anti-Adenylate cyclase 3 antibody [1A12] (red), and co-stained with anti-Tyrosine Hydroxylase antibody (green). Hoechst (blue) for nuclear staining.
