ARG42798
anti-Acetyl Coenzyme A Carboxylase antibody
anti-Acetyl Coenzyme A Carboxylase antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Acetyl Coenzyme A Carboxylase |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Acetyl-CoA Carboxylase Alpha |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human Acetyl Coenzyme A Carboxylase. |
| 偶联标记 | Un-conjugated |
| 別名 | ACC; ACACAD; Acetyl-CoA carboxylase 1; ACAC; EC 6.4.1.2; ACCA; EC 6.3.4.14; ACC-alpha; ACC1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | A431 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ACACA |
| 全名 | acetyl-CoA carboxylase alpha |
| 背景介绍 | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 266 kDa |
| 翻译后修饰 | Phosphorylation on Ser-1263 is required for interaction with BRCA1. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG42798 anti-Acetyl Coenzyme A Carboxylase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue stained with ARG42798 anti-Acetyl Coenzyme A Carboxylase antibody.
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ARG42798 anti-Acetyl Coenzyme A Carboxylase antibody WB image
Western blot: A431 cell lysate stained with ARG42798 anti-Acetyl Coenzyme A Carboxylase antibody.
