ARG45658
anti-ATP7b antibody
anti-ATP7b antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ATP7b |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ATP7b |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human ATP7b. |
| 偶联标记 | Un-conjugated |
| 別名 | ATP7B; ATPase Copper Transporting Beta; Copper-Transporting ATPase 2; Copper Pump 2; WND; ATPase, Cu++ Transporting, Beta Polypeptide; Wilson Disease-Associated Protein; PWD; WC1; ATPase, Cu++ Transporting, Beta Polypeptide (Wilson Disease); ATPase, Cu(2+)- Transporting, Beta Polypeptide; Copper-Transporting Protein ATP7B; Wilson Disease; EC 7.2.2.8; EC 3.6.3.4 47; EC 3.6.3 47; WD |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 157 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ATP7B |
| 全名 | ATPase Copper Transporting Beta |
| 背景介绍 | This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. [provided by RefSeq, Dec 2019] |
| 生物功能 | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. [UniProt] |
| 细胞定位 | Cytoplasm; Endosome; Golgi apparatus; Membrane; Mitochondrion. [UniProt] |
| 预测分子量 | 157 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG45658 anti-ATP7b antibody ICC/IF image
Immunofluorescence: CACO-2 stained with ARG45658 anti-ATP7b antibody at 5 μg/ml dilution.
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ARG45658 anti-ATP7b antibody WB image
Western blot: HepG2 stained with ARG45658 anti-ATP7b antibody at 0.5 μg/ml dilution.
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ARG45658 anti-ATP7b antibody WB image
Western blot: Rat liver stained with ARG45658 anti-ATP7b antibody at 0.5 μg/ml dilution.
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ARG45658 anti-ATP7b antibody WB image
Western blot: Mouse kidney stained with ARG45658 anti-ATP7b antibody at 0.5 μg/ml dilution.
