ARG46026
anti-ATP11A antibody
anti-ATP11A antibody for Western blot,ICC/IF and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ATP11A |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ATP11A |
| 抗原物种 | Human |
| 抗原 | A 19 amino acid synthetic peptide within the first 50 amino acids of human ATP11A. |
| 偶联标记 | Un-conjugated |
| 別名 | ATPase, class VI, type 11A; ATP11A; ATPIH; ATPIS; ATPIH; KIAA1021; Probable phospholipid-transporting ATPase IH; ATPase IS |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 纯化 | Affinity chromatography purified |
|---|---|
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -76°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P98196 Human Probable phospholipid-transporting ATPase IH Swiss-port # P98197 Mouse Probable phospholipid-transporting ATPase IH |
|---|---|
| 基因名称 | ATP11A |
| 全名 | ATPase, class VI, type 11A |
| 背景介绍 | The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. [provided by RefSeq, Apr 2022] |
| 生物功能 | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:25947375, PubMed:26567335, PubMed:29799007, PubMed:30018401, PubMed:36300302). Does not show flippase activity toward phosphatidylcholine (PC) (PubMed:34403372). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. [UniProt] |
| 细胞定位 | Cell membrane. [UniProt] |
| 预测分子量 | 130 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
