ARG46023
anti-ATG2B antibody
anti-ATG2B antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ATG2B |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ATG2B |
| 抗原物种 | Human |
| 抗原 | A 19 amino acid synthetic peptide within aa. 450 - 500 of human ATG2B. |
| 偶联标记 | Un-conjugated |
| 別名 | ATG2B; C14orf103; C14orf103; Autophagy-related protein 2 homolog B |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 纯化 | Affinity chromatography purified |
|---|---|
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -73°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q96BY7 Human Autophagy-related protein 2 homolog B |
|---|---|
| 基因名称 | ATG2B |
| 全名 | autophagy-related protein 2 homolog B |
| 背景介绍 | This gene encodes a protein required for autophagy. The encoded protein is involved in autophagosome formation. A germline duplication of a region that includes this gene is associated with predisposition to myeloid malignancies. [provided by RefSeq, Jul 2016] |
| 生物功能 | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). [UniProt] |
| 细胞定位 | Endoplasmic reticulum; Lipid droplet; Membrane. [UniProt] |
| 预测分子量 | 233 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
