ARG44701
anti-ASK1 antibody
anti-ASK1 antibody for Immunoprecipitation and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes ASK1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | ASK1 |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | ASK-1; MEK kinase 5; ASK1; MAPK/ERK kinase kinase 5; Mitogen-activated protein kinase kinase kinase 5; MEKK5; Apoptosis signal-regulating kinase 1; MEKK 5; EC 2.7.11.25; MAPKKK5; M3K5 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q99683 Human Mitogen-activated protein kinase kinase kinase 5 |
|---|---|
| 基因名称 | MAP3K5 |
| 全名 | mitogen-activated protein kinase kinase kinase 5 |
| 背景介绍 | Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death. |
| 生物功能 | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). [UniProt] |
| 细胞定位 | Cytoplasm, Endoplasmic reticulum |
| 翻译后修饰 | N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. |
检测图片 (1) Click the Picture to Zoom In
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ARG44701 anti-ASK1 antibody IP image
Immunoprecipitation: Raji lysate immunoprecipitated with 2.5 µg of ARG44701 anti-ASK1 antibody.
