概述

产品描述	Rabbit Polyclonal antibody recognizes ASIC3
反应物种	Hu
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	ASIC3
抗原物种	Human
抗原	Synthetic peptide around the internal region of Human ASIC3.
偶联标记	Un-conjugated
別名	ACCN3; Neuronal amiloride-sensitive cation channel 3; TNaC1; DRASIC; Testis sodium channel 1; hTNaC1; ASIC3; Amiloride-sensitive cation channel 3; SLNAC1; Acid-sensing ion channel 3; hASIC3

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量	~ 60 kDa

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol and 0.5% BSA
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 9311 Human ASIC3 Swiss-port # Q9UHC3 Human Acid-sensing ion channel 3
基因名称	ASIC3
全名	acid sensing (proton gated) ion channel 3
背景介绍	This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
生物功能	Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. [UniProt]
细胞定位	Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). [UniProt]
预测分子量	59 kDa
翻译后修饰	Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel (By similarity). [UniProt]

检测图片 (1) Click the Picture to Zoom In