ARG58283
anti-ASGR2 antibody
anti-ASGR2 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ASGR2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ASGR2 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 21-54 (N-terminus) of Human ASGR2. |
| 偶联标记 | Un-conjugated |
| 別名 | ASGPR 2; Hepatic lectin H2; HL-2; Asialoglycoprotein receptor 2; ASGPR2; HBXBP; CLEC4H2; ASGP-R2; C-type lectin domain family 4 member H2; ASGP-R 2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ASGR2 |
| 全名 | asialoglycoprotein receptor 2 |
| 背景介绍 | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| 生物功能 | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. [UniProt] |
| 细胞定位 | Membrane; Single-pass type II membrane protein. [UniProt] |
| 预测分子量 | 35 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG58283 anti-ASGR2 antibody WB image
Western blot: 20 µg of HepG2 cell lysate stained with ARG58283 anti-ASGR2 antibody at 1:1000 dilution.
