ARG44015
anti-ARMET antibody
anti-ARMET antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ARMET |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ARMET |
| 抗原物种 | Human |
| 抗原 | Human ARMET recombinantprotein |
| 偶联标记 | Un-conjugated |
| Protein Full name | Mesencephalic astrocyte-derived neurotrophic factor |
| 別名 | MANF; Mesencephalic Astrocyte Derived Neurotrophic Factor; ARP; Mesencephalic Astrocyte-Derived Neurotrophic Factor; ARMET; Arginine-Rich, Mutated In Early Stage Tumors; Arginine-Rich Protein; Protein ARMET |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purified. |
| 缓冲液 | PBS containing 0.02% sodium azide |
| 抗菌剂 | 0.02% sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P0C5H9 Rat Mesencephalic astrocyte-derived neurotrophic factor Swiss-port # P55145 Human Mesencephalic astrocyte-derived neurotrophic factor |
|---|---|
| 基因名称 | MANF |
| 全名 | Mesencephalic Astrocyte Derived Neurotrophic Factor |
| 背景介绍 | The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. |
| 生物功能 | Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. |
| 细胞定位 | Endoplasmic reticulum, Sarcoplasmic reticulum, Secreted |
| 预测分子量 | 20 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Phosphoprotein |
检测图片 (3) Click the Picture to Zoom In
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ARG44015 anti-ARMET antibody IHC-P image
Immunohistochemistry: Rat liver stained with ARG44015 anti-ARMET antibody at 20 μg/mL dilution.
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ARG44015 anti-ARMET antibody WB image
Western blot: 293T, A431 and A549 stained with ARG44015 anti-ARMET antibody at 15 μg/ml dilution.
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ARG44015 anti-ARMET antibody IHC-P image
Immunohistochemistry: Mouse pancreas stained with ARG44015 anti-ARMET antibody at 20 μg/mL dilution.
